Search for "5-alkyl/aryl/heteroaryl substituted 3,4-dihydro-2H-pyrrole-4,4-dicarboxylates" in Full Text gives 1 result(s) in Beilstein Journal of Organic Chemistry.
Beilstein J. Org. Chem.2011,7, 831–838, doi:10.3762/bjoc.7.95
/bjoc.7.95 Abstract A novel synthetic methodology has been developed for the synthesis of diethyl 5-alkyl/aryl/heteroarylsubstituted3,4-dihydro-2H-pyrrole-4,4-dicarboxylates (also called 2-substituted pyrroline-4,5-dihydro-3,3-dicarboxylic acid diethyl esters) by iodide ion induced ring expansion of 2
substituted novel pyrroline derivatives have been synthesized by this methodology and the products can be used as key intermediates in the synthesis of substituted pyrrolines, pyrroles and pyrrolidines.
Keywords: 5-alkyl/aryl/heteroarylsubstituted3,4-dihydro-2H-pyrrole-4,4-dicarboxylates; aziridine; N
ring expansion reaction of N-vinyl substituted aziridines was performed under mild conditions by treatment of the aziridines with anhydrous sodium iodide in acetone at room temperature to give 5-alkyl/aryl/heteroarylsubstituted3,4-dihydro-2H-pyrrole-4,4-dicarboxylates 21 in very good to excellent
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Graphical Abstract
Figure 1:
Natural products containing 2-substituted pyrroline residues in their core structural units.